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phenobarbital raises toxicity of ifosfamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. CYP3A4 inducers may raise the metabolism of ifosfamide to its active alkylating metabolites.Use in Pregnancy. Barbiturates could potentially cause fetal problems when administered to some Expecting woman. Retrospective, scenario-

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